the.com/proteomics
the genome's restless sequel, where the same DNA writes a million different protein endings.
means Proteomics is the large-scale study of the entire set of proteins produced by a cell, tissue, or organism, including how they're expressed, modified, and interact.
from A modern scientific blend from the 1990s, modeled on "genomics." It fuses "protein" with the suffix "-omics," which had spread from "genome" to mean "the complete set of" something studied as a whole. "Protein" itself comes from the Greek "prōteios," meaning "primary" or "of first rank" (from "prōtos," first) — a name coined in the 19th century to signal that these molecules were thought to be of foremost importance to life. So the word literally carries a boast about being first, now studied all at once.
- protein count
- One genome yields over a million distinct proteins
- name origin
- Coined in 1994 from protein plus genome
- mass spec
- Identifies proteins by weighing their shattered fragments
- the catch
- Proteins fold, degrade, and refuse to be copied
- living target
- Unlike DNA, the proteome shifts hour to hour
human proteome project — international collaborative effort mapping all ~20,000 human proteins, launched 2010 by hupo
cancer proteome atlas — nci initiative cataloging proteins across 32 cancer types using mass spectrometry
string database — protein-protein interaction network covering 14.8 million proteins across 5,090 organisms