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your largest organ, a self-repairing leather suit you never asked to wear

means The flexible outer covering of the body, or by extension the outer layer or surface of anything from fruit to drums to interfaces.

from From Old Norse 'skinn,' meaning hide or peltthe word brought over by Norse settlers, originally describing the flayed covering of an animal. It gradually pushed aside the older native English word 'hide,' which survives but now leans toward animals and toughness. The animal-pelt sense lingers in expressions like 'saving your skin' and 'by the skin of your teeth.'

total weightabout 8 pounds, your heaviest single organ
full rebootentirely replaced roughly every month
shed cellssheds 30,000-40,000 dead cells per minute
house dustmuch of it is your own dead skin
square footagecovers around 22 square feet unfolded
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