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That electric buzz where exhaustion and caffeine throw a party in your nervous system.

means Feeling tense, jittery, and over-alertkeyed up and unable to relax, often from caffeine, adrenaline, or sleeplessness.

from From wire, the metal thread that carries electricity. The figurative "wired" leans on the image of a live circuittaut, charged, humming with current. As electrical wiring became part of everyday life, the slang sense of a person buzzing like a charged cable followed naturally, and the caffeine-and-nerves meaning settled into common use in the 20th century.

slang originMeant drug-fueled alertness before meaning internet-connected
sleep enemyCaffeine blocks adenosine, the molecule that tells you rest
magazine fameWired launched in 1993, predicting the digital future
fight or flightAdrenaline literally wires your body for sudden action
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