the.com/wakefulness

the daily verdict your brain casts before you've earned a single thought

means The state of being awake and alert rather than asleep or drowsy.

from Built from the Old English word "wacian," meaning to be awake or to watch — the same root that gives us "watch" and "wake." Add the suffix "-ful" (full of) and "-ness" (the state of), and you get a tidy stack: the condition of being full of wakefulness. The "wak-" root traces back through Germanic to a Proto-Indo-European source possibly meaning "to be lively or vigorous," which is also thought to be a distant cousin of Latin "vigil" (watchful) — so to be wakeful and to keep vigil share old, attentive blood.

chemical switch
Orexin neurons flip you awake; their loss causes narcolepsy
record holder
Randy Gardner stayed awake 11 days in 1963
adenosine debt
Sleepiness is a molecule piling up all day
caffeine trick
It blocks adenosine, not energy you don't have
microsleeps
Exhausted brains nap for seconds, eyes open
for instance

fatal familial insomnia — genetic disorder causing progressive inability to sleep, leading to death within 7-36 months

modafinil provigil — fda-approved wakefulness-promoting drug used for narcolepsy and shift work sleep disorder

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